Blood transfusion has been an important method for saving human lives. The transfusion of blood from one person to another not only implies many medical implications but there are many Shariah perquisites to be taken into consideration due to its sensitivity. This research deals with issue of blood transfusion and its permissibility or prohibition in the light of Quranic and Prophetic evidences. The article analyzes the views of eminent scholars on the basis of Quranic and hadith evidences and elaborated them according to the contemporary and classical tafaseer books. The findings of this research support blood transfusion for saving mankind and welfare of humanity. The views of all jurists and the views of contemporary scholars also conclude the fact that Islamic teachings are for the welfare of mankind, for which blood transfusion is most important, thus it is permissible on medical grounds.