Prophet Muhammad (PBUH) was sent as a preacher for the whole world. He called the people towards Islam. Some people were misled, they did not accept Islam till the last time but caused difficulties for Muslims. Instead of these difficulties Muhammad (PBUH) did not left His goal. In the starting of Islam He preached secretly. After three years He preached openly. After that pagans of Macca became enemies of Prophet (PBUH). They created various barriers for Prophet Muhammad (PBUH) so He prevent the preaching of Islam. But he was stable. Prophet (PBUH) was discouraged by pagans of Macca, He went to outside of Macca. Besides Prophet (PBUH) visited festival, markets and bazars for preaching. He presented the Islam in front of tribe of Arab. At last He migrated to Madina. The explanation of difficulties, sufferings and behavior of the Prophet Muhammad is a lesson for preachers. Thus this research declare the Prophet Muhammad's preaching rules and regulations. So the invitee act on these rules could the preaching with ease.